Fasciola hepatica in vitro: increased susceptibility to fasciolicides in a defined serum-free medium.

@article{Jenkins1987FasciolaHI,
  title={Fasciola hepatica in vitro: increased susceptibility to fasciolicides in a defined serum-free medium.},
  author={D. Conwil Jenkins and Peter Topley and E. B. Rapson},
  journal={Parasitology},
  year={1987},
  volume={95 ( Pt 1)},
  pages={165-71}
}
The cidal properties of some phenolic, halogenated diphenyl, salicylanilide, benzimidazole and diaminophenoxyalkane anthelmintics, against 6-week-old worms of Fasciola hepatica were assessed in vitro. In a conventional fluke culture medium containing RPMI 1640, supplemented with serum with or without rabbit erythrocytes or pink-ghosts, only the halogenated diphenyl and salicylanilide compounds showed activity at concentrations equal to or less than 100 microM. However, when basal, serum and… CONTINUE READING