Fasciola hepatica fatty acid binding protein inhibits TLR4 activation and suppresses the inflammatory cytokines induced by lipopolysaccharide in vitro and in vivo.

@article{Martin2015FasciolaHF,
  title={Fasciola hepatica fatty acid binding protein inhibits TLR4 activation and suppresses the inflammatory cytokines induced by lipopolysaccharide in vitro and in vivo.},
  author={Ivelisse Martin and Kimberly Cab{\'a}n-Hern{\'a}ndez and Olgary Figueroa-Santiago and Ana M. Espino},
  journal={Journal of immunology},
  year={2015},
  volume={194 8},
  pages={3924-36}
}
TLR4, the innate immunity receptor for bacterial endotoxins, plays a pivotal role in the induction of inflammatory responses. There is a need to develop molecules that block either activation through TLR4 or the downstream signaling pathways to inhibit the storm of inflammation typically elicited by bacterial LPS, which is a major cause of the high mortality associated with bacterial sepsis. We report in this article that a single i.p. injection of 15 μg fatty acid binding protein from Fasciola… CONTINUE READING
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