Fascin is required for blood cell migration during Drosophila embryogenesis.

  title={Fascin is required for blood cell migration during Drosophila embryogenesis.},
  author={Jennifer Zanet and Brian Stramer and Thomas H. Millard and Paul Martin and Francois Payre and Serge Plaza},
  volume={136 15},
Fascin is well characterized in vitro as an actin-bundling protein and its increased expression is correlated with the invasiveness of various cancers. However, the actual roles and regulation of Fascin in vivo remain elusive. Here we show that Fascin is required for the invasive-like migration of blood cells in Drosophila embryos. Fascin expression is highly regulated during embryonic development and, within the blood lineage, is specific to the motile subpopulation of cells, which comprises… CONTINUE READING
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