Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer

@article{Grothey2000FascinAA,
  title={Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer},
  author={Axel F Grothey and Rintaro Hashizume and Aysegul A. Sahin and Pierre D. McCrea},
  journal={British Journal of Cancer},
  year={2000},
  volume={83},
  pages={870 - 873}
}
Loss of hormone receptor (HR) status in breast carcinomas is associated with increased tumour cell motility and invasiveness. In an immunohistological study of 58 primary breast cancers, oestrogen (ER) and progesterone (PR) receptor levels were inversely correlated with the expression of fascin, an actin-bundling protein associated with cell motility (P< 0.0001 and P = 0.0019, respectively). In addition, fascin was preferentially expressed in non-diploid tumours (P = 0.03). In summary, the… CONTINUE READING
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Fascin protein down regulation is required for glucocortiocoid - induced adherens and tight junctions formation in mammary epithelial cells

  • V Wong, PD McCrea, GL Firestone
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