Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells.

@article{Kumar2015FascaplysinIC,
  title={Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells.},
  author={Suresh Kumar and Santosh Kumar Guru and Anup Singh Pathania and Sudhakar Manda and Ajay Kumar and Sandip B Bharate and Ram A Vishwakarma and Fayaz Ahmed Malik and S. N. Bharath Bhushan},
  journal={Journal of cellular biochemistry},
  year={2015},
  volume={116 6},
  pages={985-97}
}
In this study, we for the first time explored the cellular and molecular mechanism of anticancer properties of fascaplysin, a marine sponge-derived alkaloid. Our study demonstrated that fascaplysin induced a cooperative interaction between apoptotic and autophagic pathways to induce cytotoxicity in HL-60 cells. Fascaplysin treatment not only activated pro-apoptotic events like PARP-1 cleavage and caspase activation but also triggered autophagy signaling as shown by the increased expression of… CONTINUE READING

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