FasL expression in activated T lymphocytes involves HuR-mediated stabilization.

  title={FasL expression in activated T lymphocytes involves HuR-mediated stabilization.},
  author={Gillian L Drury and Sergio Di Marco and Virginie Dormoy-Raclet and Julie Desbarats and Imed Eddine Gallouzi},
  journal={The Journal of biological chemistry},
  volume={285 41},
A prolonged activation of the immune system is one of the main causes of hyperproliferation of lymphocytes leading to defects in immune tolerance and autoimmune diseases. Fas ligand (FasL), a member of the TNF superfamily, plays a crucial role in controlling this excessive lymphoproliferation by inducing apoptosis in T cells leading to their rapid elimination. Here, we establish that posttranscriptional regulation is part of the molecular mechanisms that modulate FasL expression, and we show… CONTINUE READING

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