Fas transduces activation signals in normal human T lymphocytes

  title={Fas transduces activation signals in normal human T lymphocytes},
  author={Mark R. Alderson and Richard Armitage and Eugene Maraskovsky and Teresa W. Tough and Emmanuelle Roux and Kenneth A. Schooley and Fred Ramsdell and David H. Lynch},
  journal={The Journal of Experimental Medicine},
  pages={2231 - 2235}
The Fas gene encodes a cell surface molecule that is a member of the the nerve growth factor/tumor necrosis factor receptor family of proteins and can mediate programmed cell death (apoptosis) in certain transformed cell lines. To characterize further the biological function of Fas, particularly with regard to its function in normal cells, a panel of monoclonal antibodies (mAbs) was generated against the extracellular portion of human Fas. Some of these mAbs induced apoptosis in transformed… CONTINUE READING


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