Fas regulates germ cell apoptosis in the human testis in vitro.

@article{Pentikinen1999FasRG,
  title={Fas regulates germ cell apoptosis in the human testis in vitro.},
  author={Virve Pentik{\"a}inen and Krista Erkkil{\"a} and Leo Dunkel},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1999},
  volume={276 2},
  pages={E310-E316}
}
The Fas-Fas ligand (FasL) system has been implicated in maintaining the immune privileged nature of the testis. The present report concerns the role of the Fas-FasL system in regulating germ cell apoptosis, another important function of this system in the human testis. Fas was localized immunohistochemically to the same types of germ cells that were identified as apoptotic, namely spermatocytes and spermatids. Strong expression of Fas was also observed in Western blot analysis of the human… CONTINUE READING