Fas ligand gene transfer to renal allografts in rats: effects on allograft survival.


BACKGROUND Fas ligand (FasL) induces apoptosis of cells bearing its receptor Fas, and has been shown to be important in T-cell development and regulation and in immune privilege. We hypothesized that FasL expression by renal allografts might provide protection from rejection. METHODS The murine FasL cDNA was cloned into a replication-defective adenovirus… (More)


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