Fas-ligand gene silencing in basal cell carcinoma tissue with small interfering RNA

Abstract

Basal cell carcinoma (BCC) is the most frequent cancer in the Caucasian population. Cells of BCC strongly express Fas-ligand (FasL), a member of the tumor necrosis family, which induces apoptosis in Fas receptor-expressing cells. It has been suggested that by expression of FasL, BCC cells may evade the attack of Fas-positive immune effector cells allowing… (More)
DOI: 10.1038/sj.gt.3302453

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