Fas ligand expressed in colon cancer is not associated with increased apoptosis of tumor cells in vivo.

@article{Houston2003FasLE,
  title={Fas ligand expressed in colon cancer is not associated with increased apoptosis of tumor cells in vivo.},
  author={Aileen M. Houston and Frank D Waldron-Lynch and Michael R Bennett and Desmond Roche and Gerald C O'sullivan and Fergus Shanahan and J O'connell},
  journal={International journal of cancer},
  year={2003},
  volume={107 2},
  pages={209-14}
}
Expression of Fas ligand (FasL/CD95L) may help to maintain colon cancers in a state of immune privilege by inducing apoptosis of antitumor immune effector cells. Colon tumor-derived cell lines appear to be relatively insensitive to apoptosis mediated by their own or exogenous FasL in vitro, despite expression of cell surface Fas. In our present study, we sought to investigate if FasL upregulated in human colon cancers leads to any increase in apoptosis of the tumor cells in vivo. FasL and Fas… CONTINUE READING
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