Fas ligand and tumour counter-attack in colorectal cancer stratified according to microsatellite instability status.

@article{MichaelRobinson2003FasLA,
  title={Fas ligand and tumour counter-attack in colorectal cancer stratified according to microsatellite instability status.},
  author={Julie M Michael-Robinson and Nirmala Pandeya and Margaret C. Cummings and M. D. Walsh and Joanne P. Young and Barbara A. Leggett and David M. Purdie and Jeremy R. Jass and Graham L Radford-Smith},
  journal={The Journal of pathology},
  year={2003},
  volume={201 1},
  pages={46-54}
}
Expression of membrane-bound Fas ligand (FasL) by colorectal cancer cells may allow the development of an immune-privileged site by eliminating incoming tumour-infiltrating lymphocytes (TILs) in a Fas-mediated counter-attack. Sporadic colorectal cancer can be subdivided into three groups based on the level of DNA microsatellite instability (MSI). High-level MSI (MSI-High) is characterized by the presence of TILs and a favourable prognosis, while microsatellite-stable (MSS) cancers are TIL… CONTINUE READING

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