Fas ligand and Fas receptor are coexpressed in normal human esophageal epithelium: a potential mechanism of apoptotic epithelial turnover.

@article{Bennett1999FasLA,
  title={Fas ligand and Fas receptor are coexpressed in normal human esophageal epithelium: a potential mechanism of apoptotic epithelial turnover.},
  author={Michael R Bennett and J O'connell and G C O'sullivan and Desmond Roche and Ciaran M Brady and John Kevin Collins and Fergus Shanahan},
  journal={Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus},
  year={1999},
  volume={12 2},
  pages={
          90-8
        }
}
Fas (CD95/Apo-1) receptor (FasR) is a cell-surface receptor that mediates apoptotic cell death upon triggering by Fas ligand (FasL). We sought to determine whether normal human esophageal epithelial cells express FasL and/or FasR and whether their localization is consistent with a role in the turnover of normal esophageal epithelium. Normal esophageal epithelium was immunohistochemically positive for FasL in upper prickle cell layers and in mature squamous cells, but the proliferative basal… CONTINUE READING

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