Fas ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL-1, IL-6, TNF-alpha, or IFN-gamma.

@article{Choi1999FasLA,
  title={Fas ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL-1, IL-6, TNF-alpha, or IFN-gamma.},
  author={Chong Hyuk Choi and Ju Youn Park and J C Lee and Jae Hyang Lim and Eui-Cheol Shin and Young Sup Ahn and Chang H Kim and Se Jong Kim and Jung Dae Kim and Inseok Stephen Choi and I-K. Choi},
  journal={Journal of immunology},
  year={1999},
  volume={162 4},
  pages={
          1889-95
        }
}
Fas ligand (FasL) and Fas are mediators of apoptosis, which are implicated in the peripheral deletion of autoimmune cells, activation-induced T cell death, and cytotoxicity mediated by CD8+ T cells. Fas is also believed to be involved in several central nervous system diseases, but until now, the effector cells expressing FasL in the brain have not been identified. We investigated the expression levels of Fas and FasL with the stimulation of cytokines and the possible effector cells targeting… CONTINUE READING
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