Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire.

@article{Takahashi2001FasIR,
  title={Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire.},
  author={Yoshimasa Takahashi and Hiroshi Ohta and Toshitada Takemori},
  journal={Immunity},
  year={2001},
  volume={14 2},
  pages={181-92}
}
In T cell-dependent immune responses, high-affinity B cells are selected and differentiate into memory cells; however, the mechanism behind this process remains largely unknown. Here, we report that the selection of high-affinity B cells within germinal centers (GCs) is impaired in Fas-deficient lpr mice in the primary response, probably owing to inefficient negative selection. The memory compartment in control mice is mostly established by precursors generated from the early GCs, whereas the… CONTINUE READING
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