Fas-induced arachidonic acid release is mediated by Ca2+-independent phospholipase A2 but not cytosolic phospholipase A2, which undergoes proteolytic inactivation.

Abstract

Fas-mediated apoptosis of human leukemic U937 cells was accompanied by increased arachidonic acid (AA) and oleic acid release from membrane glycerophospholipids, indicating phospholipase A2 (PLA2) activation. During apoptosis, type IV cytosolic PLA2 (cPLA2), a PLA2 isozyme with an apparent molecular mass of 110 kDa critical for stimulus-coupled AA release… (More)

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@article{Atsumi1998FasinducedAA, title={Fas-induced arachidonic acid release is mediated by Ca2+-independent phospholipase A2 but not cytosolic phospholipase A2, which undergoes proteolytic inactivation.}, author={Gen-ichi Atsumi and Motoshi Tajima and Atsuko Hadano and Yuki Nakatani and Masami Murakami and Ichiro Kudo}, journal={The Journal of biological chemistry}, year={1998}, volume={273 22}, pages={13870-7} }