Fas expression prevents cholangiocarcinoma tumor growth

  title={Fas expression prevents cholangiocarcinoma tumor growth},
  author={Allan Pickens and George Pan and J. M. Mcdonald and Selwyn Maurice Vickers},
  journal={Journal of Gastrointestinal Surgery},
Cholangiocarcinoma continues to have a dismal prognosis with an overall survival rate of less than 10%. An increased understanding of the molecular oncogenesis of this tumor is needed. Fas/APO-1 (CD95) receptor and Fas ligand have been implicated as key factors in apoptosis. In this study we have examined the role of the Fas receptor in the growth of cholangiocarcinoma. The purpose of this study was to evaluate the role of the Fas receptor in the induction of apoptosis in cholangiocarcinoma and… CONTINUE READING