Fas expression in nephrectomized, non-cancerous specimens predicts post-nephrectomy chronic kidney disease progression in patients with renal and upper urinary tract malignancies.

@article{Sejima2013FasEI,
  title={Fas expression in nephrectomized, non-cancerous specimens predicts post-nephrectomy chronic kidney disease progression in patients with renal and upper urinary tract malignancies.},
  author={Takehiro Sejima and Hideto Iwamoto and Shuichi Morizane and Nobuyuki Hinata and Akihisa Yao and Tadahiro Isoyama and Motoaki Saito and Takashi Amisaki and Atsushi Takenaka},
  journal={Urologic oncology},
  year={2013},
  volume={31 8},
  pages={1812-9}
}
OBJECTIVES Despite the surgical curability of renal cell carcinoma (RCC) and upper urinary tract urothelial carcinoma (UUT-UC), post-nephrectomy chronic kidney disease (CKD) continues to be a cause of concern. We investigated the correlation between the expression of apoptotic regulatory molecules in the nephrectomized, noncancerous cortex, as well as CKD progression and CKD-related mortality. MATERIALS AND METHODS Fas and Bcl-2 mRNA and protein expression in surgically resected specimens… CONTINUE READING