Fas-deficient lpr mice are more susceptible to graft-versus-host disease.

@article{Brink2000FasdeficientLM,
  title={Fas-deficient lpr mice are more susceptible to graft-versus-host disease.},
  author={Marcel R M van den Brink and Ellen E. Moore and K J Horndasch and James Mack Crawford and Jennifer R Hoffman and George Murphy and Steven J. Burakoff},
  journal={Journal of immunology},
  year={2000},
  volume={164 1},
  pages={
          469-80
        }
}
The Fas/Fas ligand (FasL) pathway is involved in a variety of regulatory mechanisms that could be important for the development of graft-vs-host disease (GVHD) after bone marrow transplantation (BMT), such as cytolysis of target cells by cytotoxic T cells, regulation of inflammatory responses, peripheral deletion of autoimmune cells, costimulation of T cells, and activation-induced cell death. To further evaluate the role of Fas/FasL in the complex pathophysiology of GVHD, we used Fas-deficient… CONTINUE READING
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