Fas and TNFR1, but not cytolytic granule-dependent mechanisms, mediate clearance of murine liver adenoviral infection.

@article{Abougergi2005FasAT,
  title={Fas and TNFR1, but not cytolytic granule-dependent mechanisms, mediate clearance of murine liver adenoviral infection.},
  author={Marwan S. Abougergi and Sarah J Gidner and David K Spady and Bonnie C. Miller and Dwain L. Thiele},
  journal={Hepatology},
  year={2005},
  volume={41 1},
  pages={97-105}
}
After intravenous injection of replication-deficient adenovirus, hepatocytes are transduced and express high levels of adenovirus-encoded genes. However, adenovirally encoded gene expression is ablated rapidly by CD8+ T-cell-dependent mechanisms. Thus, this model is suitable for examining intrahepatic cytotoxic T lymphocyte (CTL) effector mechanisms. In the present studies, recombinant adenoviruses encoding secreted (human apolipoprotein A-I) or intracellular (beta-galactosidase) gene products… CONTINUE READING

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