Fas and FasL in the homeostatic regulation of immune responses.

@article{Lynch1995FasAF,
  title={Fas and FasL in the homeostatic regulation of immune responses.},
  author={David H. Lynch and Fred Ramsdell and Mark R. Alderson},
  journal={Immunology today},
  year={1995},
  volume={16 12},
  pages={569-74}
}
Studies of the biological effects of Fas signaling, using transformed cell lines as targets, indicate that ligation of the Fas receptor induces an apoptotic death signal. Chronically activated normal human T cells are also susceptible to Fas-mediated apoptosis. However, interactions between Fas and Fas ligand can also yield a costimulatory signal. Here, David Lynch, Fred Ramsdell and Mark Alderson present a model for the role of As and FasL in the homeostatic regulation of normal immune… CONTINUE READING