Fas and Fas Ligand Immunolocalization in Pancreatic Islets of NOD Mice during Spontaneous and Cyclophosphamide-accelerated Diabetes

@article{Reddy2002FasAF,
  title={Fas and Fas Ligand Immunolocalization in Pancreatic Islets of NOD Mice during Spontaneous and Cyclophosphamide-accelerated Diabetes},
  author={Shiva Kumar Reddy and Suyin Ginn and Jacqueline M. Ross},
  journal={The Histochemical Journal},
  year={2002},
  volume={34},
  pages={1-12}
}
During insulin-dependent diabetes mellitus, immune cells which infiltrate pancreatic islets mediate beta cell destruction over a prolonged asymptomatic prediabetic period. The molecular mechanisms of beta cell death in vivo remain unresolved. At least two major molecular processes of destruction have been proposed. One involves the Fas–FasL (Fas–Fas ligand) system and the other, the perforin pathway. Here, dual-label immunohistochemistry was employed to examine the intra-islet expression… CONTINUE READING
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References

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The role of Fas in autoimmune diabetes

  • AV Chervonsky, FS Wong, RA Flavell, CA Janeway, LA Matis
  • Cell
  • 1997
Highly Influential
6 Excerpts

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