Fas-Independent T-Cell Apoptosis by Dendritic Cells Controls Autoimmune Arthritis in MRL/lpr Mice

@inproceedings{Izawa2012FasIndependentTA,
  title={Fas-Independent T-Cell Apoptosis by Dendritic Cells Controls Autoimmune Arthritis in MRL/lpr Mice},
  author={Takashi Izawa and Tomoyuki Kondo and Mie Kurosawa and Ritsuko Oura and Kazuma Matsumoto and Eiji Tanaka and Akiko Yamada and Rieko Arakaki and Yasusei Kudo and Yoshio Hayashi and Naozumi Ishimaru},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Although autoimmunity in MRL/lpr mice occurs due to a defect in Fas-mediated cell death of T cells, the role of Fas-independent apoptosis in pathogenesis has rarely been investigated. We have recently reported that receptor activator of nuclear factor (NF)-κB ligand (RANKL)-activated dendritic cells (DCs) play a key role in the pathogenesis of rheumatoid arthritis (RA) in MRL/lpr mice. We here attempted to establish a new therapeutic strategy with RANKL-activated DCs in RA by… CONTINUE READING