Fas-FasL interaction modulates nitric oxide production in Trypanosoma cruzi-infected mice.

@article{Martins2001FasFasLIM,
  title={Fas-FasL interaction modulates nitric oxide production in Trypanosoma cruzi-infected mice.},
  author={Gisl{\^a}ine Aparecida Martins and Stefka B. Petkova and Fabiana Sim{\~a}o Machado and Richard N Kitsis and Louis M Weiss and Monika Wittner and Herbert B Tanowitz and Jo{\~a}o S. Silva},
  journal={Immunology},
  year={2001},
  volume={103 1},
  pages={122-9}
}
During acute Trypanosoma cruzi infection in mice, many leucocytes undergo apoptosis. Although apoptosis has been ascribed to increased levels of nitric oxide (NO) and Fas-FasL interaction, the importance of this phenomenon in modulating the host response against T. cruzi is unknown. Herein, the role of NO- and Fas-FasL-induced apoptosis in modulating the immune response to T. cruzi was evaluated using mice deficient in Fas expression (MRL/MpJ-Fas lpr) and inducible nitric oxide synthase (iNOS… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…