Fas (TNFRSF6) Gene Polymorphism in Pregnant Women With Hemolysis, Elevated Liver Enzymes, and Low Platelets and in Their Neonates

  title={Fas (TNFRSF6) Gene Polymorphism in Pregnant Women With Hemolysis, Elevated Liver Enzymes, and Low Platelets and in Their Neonates},
  author={Istv{\'a}n Sziller and Petronella Hupuczi and Neil Normand and Amrita Halmos and Zolt{\'a}n Papp and Steven Sol Witkin},
  journal={Obstetrics \& Gynecology},
OBJECTIVE: To estimate whether an A>G polymorphism at position −670 in the gene coding for Fas (gene symbol TNFRSF6) is associated with hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. METHODS: In a retrospective study, buccal swabs from 81 women with the complete form of HELLP syndrome and 83 normotensive control women with uncomplicated full-term pregnancy, and 110 of their neonates, were analyzed for the presence of the TNFRSF6–670 polymorphism. Investigators were blinded… 
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