Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice.

@article{Kitamura2001FasFasLdependentAO,
  title={Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice.},
  author={Yoshihiro Kitamura and Satoru Hashimoto and Naruhiko Mizuta and Atsuko K. Kobayashi and Kunihiko Kooguchi and Ikuya Fujiwara and Hiroshi Nakajima},
  journal={American journal of respiratory and critical care medicine},
  year={2001},
  volume={163 3 Pt 1},
  pages={
          762-9
        }
}
To determine the possible contribution of apoptosis in the pathogenesis of acute lung injury (ALI), we investigated Fas antigen (Fas), Fas ligand (FasL), perforin, granzyme A, and granzyme B expressions in a murine model of ALI after intratracheal instillation of Escherichia coli lipopolysaccharide (LPS: 0.3-30 microg) into the left lung. Lung injury, examined by water-to-dry weight ratio and albumin leakage, demonstrated maximal epithelial injury 1 d after 30 microg LPS instillation… CONTINUE READING

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