Fas/Fas ligand system in prolactin-induced apoptosis in rat corpus luteum: possible role of luteal immune cells.

@article{Kuranaga1999FasFasLS,
  title={Fas/Fas ligand system in prolactin-induced apoptosis in rat corpus luteum: possible role of luteal immune cells.},
  author={Erina Kuranaga and Hirotaka Kanuka and Makoto Bannai and Masako Suzuki and Masugi Nishihara and Mayumi Takahashi},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={260 1},
  pages={167-73}
}
The prolactin (PRL) surge in cycling rats during the proestrous afternoon is an inducer of apoptotic cell death in luteal cells. This luteolytic action of PRL is peculiar, because PRL may be categorized as a survival factor, if other known physiological functions of PRL are taken into account. Here we analyzed the underlying molecular/cellular mechanisms of this PRL-induced apoptosis. Corpora lutea (CL) were prepared from the ovary on the proestrous day and cultured with or without PRL (2… CONTINUE READING

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