Farnesyltransferase inhibitors-induced autophagy: alternative mechanisms?

Abstract

Farnesyltransferase inhibitors (FTIs) were designed to block the action of Ras oncoproteins which depend on posttranslational modification by adding a farnesyl isoprenoid membrane anchor. However, off-target actions are believed to account for most of their antitumor activity. We recently reported the induction of autophagy in cancer cells in a dose… (More)

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Cite this paper

@article{Pan2009FarnesyltransferaseIA, title={Farnesyltransferase inhibitors-induced autophagy: alternative mechanisms?}, author={Jingxuan Pan and Enlin Song and Chao Cheng and Mong Hong Lee and Sai Ching Yeung}, journal={Autophagy}, year={2009}, volume={5 1}, pages={129-31} }