Farnesyltransferase inhibitors in breast cancer therapy.

  title={Farnesyltransferase inhibitors in breast cancer therapy.},
  author={Grace Kho Dy and Araba A. Adjei},
  journal={Cancer investigation},
  volume={20 Suppl 2},
Farnesyltransferase inhibitors (FTIs) belong to a group of agents originally designed to prevent membrane attachment of Ras protein by inhibiting a key step in its post-translational processing. It was thus hypothesized that FTIs would curtail the oncogenic ras-mediated proliferative and antiapoptotic signals that are activated in human tumors. Although the Ras protein is mutated in only < 5% of breast cancers, there are multiple aberrant pathways that lead to activation of wild-type ras… CONTINUE READING
10 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…