Farnesyltransferase inhibitors in breast cancer therapy.

@article{Dy2002FarnesyltransferaseII,
  title={Farnesyltransferase inhibitors in breast cancer therapy.},
  author={Grace Kho Dy and Araba A. Adjei},
  journal={Cancer investigation},
  year={2002},
  volume={20 Suppl 2},
  pages={30-7}
}
Farnesyltransferase inhibitors (FTIs) belong to a group of agents originally designed to prevent membrane attachment of Ras protein by inhibiting a key step in its post-translational processing. It was thus hypothesized that FTIs would curtail the oncogenic ras-mediated proliferative and antiapoptotic signals that are activated in human tumors. Although the Ras protein is mutated in only < 5% of breast cancers, there are multiple aberrant pathways that lead to activation of wild-type ras… CONTINUE READING
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