Farnesyltransferase inhibitors as anticancer agents: current status.

@article{Zhu2003FarnesyltransferaseIA,
  title={Farnesyltransferase inhibitors as anticancer agents: current status.},
  author={Kuichun Zhu and Andrew D. Hamilton and Sa{\"i}d M. Sebti},
  journal={Current opinion in investigational drugs},
  year={2003},
  volume={4 12},
  pages={1428-35}
}
Farnesyltransferase (FTase) is a major molecular target for the development of novel anticancer drugs that are designed to disrupt the aberrant signal transduction circuitry of tumor cells. The discovery more than a decade ago that farnesylation of Ras, one of the most prevalent oncoproteins in human cancers, is required for its cancer-causing activity was… CONTINUE READING