Farnesyltransferase inhibitor, R115777, reverses the resistance of human glioma cell lines to ionizing radiation.

@article{Delmas2002FarnesyltransferaseIR,
  title={Farnesyltransferase inhibitor, R115777, reverses the resistance of human glioma cell lines to ionizing radiation.},
  author={Caroline Delmas and Christophe H{\'e}liez and Elizabeth Moyal Cohen-Jonathan and Dave W End and Jacques E Bonnet and Gilles Favre and Christine Toulas},
  journal={International journal of cancer},
  year={2002},
  volume={100 1},
  pages={43-8}
}
We investigated for the first time the ability of farnesyltransferase inhibitors (FTI) to radiosensitize human glioma. For this, human glioma cell lines were treated with the specific FTI, R115777, 48 hr prior to a 2Gy irradiation. The treatment with R115777 decreased by 45% the SF2 value of the more radioresistant glioma cell lines (SF763 and U87) without any significant effect on the radioresistance of the radiosensitive ones (SF767 and U251-MG). This radiosensitizer effect was due to the… CONTINUE READING

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