Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells

  title={Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells},
  author={Masahiro Hamada and Kyoichi Nishio and Matsumi Doe and Yoshinosuke Usuki and Toshio Tanaka},
  journal={FEBS Letters},

Inhibitory activity of 1-farnesylpyridinium on the spatial control over the assembly of cell wall polysaccharides in Schizosaccharomyces pombe.

The results suggest the inhibitory activity of FPy on the spatial control over the assembly of cell wall polysaccharides in Schizosacchromyces pombe may interfere with the following morphogenetic process for construction of the rod-shaped cell wall architecture.

Studies of the Isoprenoid-Mediated Inhibition of Mevalonate Synthesis Applied to Cancer Chemotherapy and Chemoprevention

  • H. MoC. Elson
  • Biology, Chemistry
    Experimental biology and medicine
  • 2004
Diverse isoprenoids and the HMG CoA reductase inhibitor, lovastatin, modulate cell growth, induce cell cycle arrest, initiate apoptosis, and suppress cellular signaling activities, and potentially offer a novel chemotherapeutic strategy free of the dose-limiting toxicities.

Ham-Wasserman lecture: treatment of acute leukemia by inducing differentiation and apoptosis.

  • Zhen-yi Wang
  • Medicine, Biology
    Hematology. American Society of Hematology. Education Program
  • 2003
Progress at the molecular level has been achieved in explaining the mechanisms of action of ATRA and arsenic compounds, and several new agents have emerged, although their clinical effectiveness remains to be confirmed.

Improved production of isoamyl acetate by a sake yeast mutant resistant to an isoprenoid analog and its dependence on alcohol acetyltransferase activity, but not on isoamyl alcohol production.

The FPy-resistant mutant A1 was characterized by the high production of flavor compounds represented by a nearly threefold increase in the level of isoamyl acetate in YPD medium in which thelevel of iso amyl alcohol as its precursor remained almost unchanged.

Isolation of a Copper-resistant Sake Yeast Mutant with Improved Flavour Compound Production

The sake (traditional Japanese alcoholic beverage) yeast mutant A1 was previously isolated as a strain resistant to an isoprenoid analog. This strain is used for industrial sake brewing because of

Various oils and detergents enhance the microbial production of farnesol and related prenyl alcohols.

It was found that oils and detergents significantly enhanced the extracellular production of prenyl alcohols and Soybean oil showed the most prominent effect among the additives tested.

Hard clam extracts induce atypical apoptosis in human gastric cancer cells

It was revealed that HC extracts interrupted cell cycle progression in AGS cells through altered expression of six cell cycle-associated genes: CDC20, KPNA2, BIRC5, ANAPC2, CDKN1A and RB1, suggesting that HC may contribute to a novel future anticancer agent.



Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis.

It is demonstrated that microfilament assembly is necessary for the formation of apoptotic bodies in the later stages of the apoptotic process, as opposed to the earlier phase, when DNA fragmentation occurs and cell shrinkage and dilation of the endoplasmic reticulum occurs.

Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells.

A inhibitor that preferentially inhibits the caspase-3 related caspases, Z-DEVD-FMK, strongly blocked the GGO-induced DNA fragmentation and suggest the involvement of caspasing-3 in G GO-induced apoptosis in U937 human leukemia cells.

Selective Activation of Caspases During Apoptotic Induction in HL-60 Cells

The results suggest that selective activation of some caspases is necessary to induce apoptosis in HL-60 cells, suggesting that blockage of caspase activity is able to protect cells.

Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki‐ras–transformed fibroblasts

The results indicate that the mechanism of cell death induced by farnesylamine is apoptosis, and this apoptosis occurred specifically in pancreatic carcinoma cells containing mutated Ki‐ras and the Ki-ras–transformed cells.

Induction of apoptosis by all-trans retinoic acid in the human myeloma cell line RPMI 8226 and negative regulation of some of its typical morphological features by dexamethasone

Data demonstrate that key cytoplasmic and nuclear events occurring during apoptosis are differentially regulated by RA and Dex in myeloma cell line RPMI’8226.

Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids.

Beta-Ionone and lovastatin interfered with the posttranslational processing of lamin B, an activity essential to assembly of daughter nuclei, which renders neosynthesized DNA available to the endonuclease activities leading to apoptotic cell death, and arrested cells in the G1 phase of the cell cycle.