Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells

@article{Hamada2002FarnesylpyridiniumAA,
  title={Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells},
  author={Masahiro Hamada and Kyoichi Nishio and Matsumi Doe and Yoshinosuke Usuki and Toshio Tanaka},
  journal={FEBS Letters},
  year={2002},
  volume={514}
}

Inhibitory activity of 1-farnesylpyridinium on the spatial control over the assembly of cell wall polysaccharides in Schizosaccharomyces pombe.

TLDR
The results suggest the inhibitory activity of FPy on the spatial control over the assembly of cell wall polysaccharides in Schizosacchromyces pombe may interfere with the following morphogenetic process for construction of the rod-shaped cell wall architecture.

Studies of the Isoprenoid-Mediated Inhibition of Mevalonate Synthesis Applied to Cancer Chemotherapy and Chemoprevention

  • H. MoC. Elson
  • Biology, Chemistry
    Experimental biology and medicine
  • 2004
TLDR
Diverse isoprenoids and the HMG CoA reductase inhibitor, lovastatin, modulate cell growth, induce cell cycle arrest, initiate apoptosis, and suppress cellular signaling activities, and potentially offer a novel chemotherapeutic strategy free of the dose-limiting toxicities.

Ham-Wasserman lecture: treatment of acute leukemia by inducing differentiation and apoptosis.

  • Zhen-yi Wang
  • Medicine, Biology
    Hematology. American Society of Hematology. Education Program
  • 2003
TLDR
Progress at the molecular level has been achieved in explaining the mechanisms of action of ATRA and arsenic compounds, and several new agents have emerged, although their clinical effectiveness remains to be confirmed.

Improved production of isoamyl acetate by a sake yeast mutant resistant to an isoprenoid analog and its dependence on alcohol acetyltransferase activity, but not on isoamyl alcohol production.

TLDR
The FPy-resistant mutant A1 was characterized by the high production of flavor compounds represented by a nearly threefold increase in the level of isoamyl acetate in YPD medium in which thelevel of iso amyl alcohol as its precursor remained almost unchanged.

Isolation of a Copper-resistant Sake Yeast Mutant with Improved Flavour Compound Production

The sake (traditional Japanese alcoholic beverage) yeast mutant A1 was previously isolated as a strain resistant to an isoprenoid analog. This strain is used for industrial sake brewing because of

Various oils and detergents enhance the microbial production of farnesol and related prenyl alcohols.

TLDR
It was found that oils and detergents significantly enhanced the extracellular production of prenyl alcohols and Soybean oil showed the most prominent effect among the additives tested.

Hard clam extracts induce atypical apoptosis in human gastric cancer cells

TLDR
It was revealed that HC extracts interrupted cell cycle progression in AGS cells through altered expression of six cell cycle-associated genes: CDC20, KPNA2, BIRC5, ANAPC2, CDKN1A and RB1, suggesting that HC may contribute to a novel future anticancer agent.

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