Farnesyl transferase inhibitors induce neuroprotection by inhibiting Ha-Ras signalling pathway.

@article{Ruocco2007FarnesylTI,
  title={Farnesyl transferase inhibitors induce neuroprotection by inhibiting Ha-Ras signalling pathway.},
  author={Antonio Ruocco and Mariarosaria Santillo and Maria Cicale and Rosalba Ser{\`u} and Giovanni Cuda and Josef Anrather and C Iadecola and Alfredo Postiglione and Enrico Vittorio Avvedimento and Roberto Patern{\`o}},
  journal={The European journal of neuroscience},
  year={2007},
  volume={26 11},
  pages={3261-6}
}
In previous studies we found that the GTPase p21 Harvey-Ras (Ha-Ras) stimulates the production of reactive oxygen species and induces apoptosis by oxidative stress; this effect was reversed by farnesyl transferase inhibitors (FTIs). In this study we investigated whether FTIs reduce rat brain damage induced by an excitotoxic stimulus, and the signalling pathway(s) underlying the neuroprotection by FTIs. In brain tissue, protein levels of Ha-Ras and farnesylation inhibition were assayed by… CONTINUE READING

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