Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones.

@article{Moasser1998FarnesylTI,
  title={Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones.},
  author={Mark M Moasser and Laura Sepp-Lorenzino and Nancy E. Kohl and Biju Mangatt and Aaron Balog and Dian San Su and Samuel J Danishefsky and Neal Rosen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 4},
  pages={
          1369-74
        }
}
An important class of cellular proteins, which includes members of the p21ras family, undergoes posttranslational farnesylation, a modification required for their partition to membranes. Specific farnesyl transferase inhibitors (FTIs) have been developed that selectively inhibit the processing of these proteins. FTIs have been shown to be potent inhibitors of tumor cell growth in cell culture and in murine models and at doses that cause little toxicity to the animal. These data suggest that… CONTINUE READING

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