Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3.

@article{Bang2010FarnesylPI,
  title={Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3.},
  author={Sangsu Bang and Sungjae Yoo and Tae-Jin Yang and Hawon Cho and Sun Wook Hwang},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 25},
  pages={19362-71}
}
Temperature-sensitive transient receptor potential ion channels (thermoTRPs) expressed in epidermal keratinocytes and sensory afferents play an important role as peripheral pain detectors for our body. Many natural and synthetic compounds have been found to act on the thermoTRPs leading to altered nociception, but little is known about endogenous painful… CONTINUE READING