Farnesol-mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue.

@article{Uppuluri2007FarnesolmediatedIO,
  title={Farnesol-mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue.},
  author={Priya Uppuluri and Satish Mekala and W. LaJean Chaffin},
  journal={Yeast},
  year={2007},
  volume={24 8},
  pages={681-93}
}
During Candida albicans yeast cell growth to early stationary phase, metabolites accumulate in the medium, including the quorum-sensing molecule farnesol. We found that besides germ tube inhibition, 40 microM farnesol also inhibited C. albicans yeast growth under yeast growth permissive conditions. Consistent with this observation, transcriptional analysis of yeast cells resuspended in fresh medium with 40 microM farnesol revealed that genes involved in hyphal formation, GTPase activation… CONTINUE READING
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