Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

@article{Prawitt2011FarnesoidXR,
  title={Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity},
  author={J. Prawitt and Mouaadh Abdelkarim and J. H. Stroeve and I. Popescu and H. Duez and V. Velagapudi and J. Dumont and Emmanuel Bouchaert and T. V. van Dijk and A. Lucas and Emilie Dorchies and M. Daoudi and S. Lestavel and F. Gonzalez and M. Ore{\vs}i{\vc} and B. Cariou and F. Kuipers and S. Caron and B. Staels},
  journal={Diabetes},
  year={2011},
  volume={60},
  pages={1861 - 1871}
}
OBJECTIVE Bile acids (BA) participate in the maintenance of metabolic homeostasis acting through different signaling pathways. The nuclear BA receptor farnesoid X receptor (FXR) regulates pathways in BA, lipid, glucose, and energy metabolism, which become dysregulated in obesity. However, the role of FXR in obesity and associated complications, such as dyslipidemia and insulin resistance, has not been directly assessed. RESEARCH DESIGN AND METHODS Here, we evaluate the consequences of FXR… Expand
Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice
The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer
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