Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

@article{Schuijs2015FarmDA,
  title={Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells},
  author={Martijn J. Schuijs and Monique A. M. Willart and Karl Vergote and Delphine Gras and Kim Deswarte and Markus J Ege and Filipe Branco Madeira and Rudi Beyaert and G. C. van Loo and Franz Bracher and Erika von Mutius and Pascal Chanez and Bart M. Lambrecht and Hamida Hammad},
  journal={Science},
  year={2015},
  volume={349},
  pages={1106-1110}
}
Growing up on a dairy farm protects children from allergy, hay fever, and asthma. A mechanism linking exposure to this endotoxin (bacterial lipopolysaccharide)–rich environment with protection has remained elusive. Here we show that chronic exposure to low-dose endotoxin or farm dust protects mice from developing house dust mite (HDM)–induced asthma. Endotoxin reduced epithelial cell cytokines that activate dendritic cells (DCs), thus suppressing type 2 immunity to HDMs. Loss of the ubiquitin… CONTINUE READING

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