Faricimab: an investigational agent targeting the Tie-2/angiopoietin pathway and VEGF-A for the treatment of retinal diseases

@article{Nicol2021FaricimabAI,
  title={Faricimab: an investigational agent targeting the Tie-2/angiopoietin pathway and VEGF-A for the treatment of retinal diseases},
  author={Massimo Nicol{\`o} and Lorenzo Ferro Desideri and Aldo Vagge and Carlo E Traverso},
  journal={Expert Opinion on Investigational Drugs},
  year={2021},
  volume={30},
  pages={193 - 200}
}
ABSTRACT Introduction Intravitreal antivascular endothelial growth factor (VEGF) drugs represent the first-line treatment option for wet age-related macular degeneration (w-AMD) and diabetic macular edema (DME); however, the frequent injection intervals have illuminated to the necessity for new molecules allowing a more prolonged treatment regimen. Faricimab is a promising bispecific drug targeting VEGF-A and the Ang-Tie/pathway. Phase II STAIRWAY and AVENUE Trials showed its clinical efficacy… 
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