Fangchinoline inhibits breast adenocarcinoma proliferation by inducing apoptosis.

  title={Fangchinoline inhibits breast adenocarcinoma proliferation by inducing apoptosis.},
  author={Zhi-Bo Xing and Lei Yao and Guo-Qiang Zhang and Xian-yu Zhang and You-xue Zhang and D Y Pang},
  journal={Chemical & pharmaceutical bulletin},
  volume={59 12},
Radix Stephaniae tetrandrae, which contains tetrandrine (Tet) and fangchinoline, is traditionally used as an analgesic, antirheumatic, and antihypertensive drug in China. In this study, we investigated its effect on breast cancer cell proliferation and its potential mechanism of action in vitro. Treatment of cells with fangchinoline significantly inhibited MDA-MB-231 cell proliferation in a concentration- and time-dependent manner. To define the mechanism underlying the antiproliferative… CONTINUE READING


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