Fanconi anemia proteins stabilize replication forks.

@article{Wang2008FanconiAP,
  title={Fanconi anemia proteins stabilize replication forks.},
  author={Lily C. Wang and Stacie Stone and Maureen E. Hoatlin and Jean Gautier},
  journal={DNA repair},
  year={2008},
  volume={7 12},
  pages={
          1973-81
        }
}
Fanconi anemia (FA) is a recessive genetic disorder characterized by hypersensitivity to crosslinking agents that has been attributed to defects in DNA repair and/or replication. FANCD2 and the FA core complex bind to chromatin during DNA replication; however, the role of FA proteins during replication is unknown. Using Xenopus cell-free extracts, we show that FANCL depletion results in defective DNA replication restart following treatment with camptothecin, a drug that results in DSBs during… CONTINUE READING

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