Fanconi anaemia: genetics, molecular biology, and cancer – implications for clinical management in children and adults.

@article{Schneider2015FanconiAG,
  title={Fanconi anaemia: genetics, molecular biology, and cancer – implications for clinical management in children and adults.},
  author={Marion Schneider and Kate E. Chandler and Marc Tischkowitz and Stefan Meyer},
  journal={Clinical genetics},
  year={2015},
  volume={88 1},
  pages={13-24}
}
Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities, cross-linker hypersensitivity and extreme cancer predisposition. With better understanding of the genetic and molecular basis of the disease, and improved clinical management, FA has been transformed from a life-limiting paediatric disease to an uncommon chronic condition that needs lifelong multidisciplinary management, and a paradigm condition for the understanding of the gene-environment interaction… CONTINUE READING