Famotidine polymorphic transformation in the grinding process significantly depends on environmental humidity or water content.


The effect of environmental humidity and additional water added on the polymorphic change of famotidine in the process of grinding was investigated. The famotidine form B powder with or without additional amount of water added was respectively ground for 30 min in an oscillatory ball mill under 25+/-2 degrees C and three relative humidities (RH) (50+/-5… (More)
DOI: 10.1016/j.ijpharm.2008.01.048


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