Famotidine and Omeprazole Both Induce Gastric Transmucosal Leak

  title={Famotidine and Omeprazole Both Induce Gastric Transmucosal Leak},
  author={David C. Rudolph and Mary Carmen Valenzano and Benjamin Ngo and Keith R Kearney and Giancarlo Mercogliano and James M Mullin},
Background: Our group has recently published that proton pump inhibitors (PPIs) induce transmucosal, paracellular, bidirectional leakage in the gastric corpus epithelium to a wide range of molecules. Aim: This study was undertaken to determine if H-2 blocker medications also induce such leakage, or whether it is a result of specific inhibition of H + ,K + -ATPase. Methods: At the beginning and end of a dosage regimen of omeprazole or famotidine, healthy volunteers with no history of… CONTINUE READING