Family with sequence similarity 13C (FAM13C) overexpression is an independent prognostic marker in prostate cancer

  title={Family with sequence similarity 13C (FAM13C) overexpression is an independent prognostic marker in prostate cancer},
  author={Christoph Burdelski and Laura Borcherding and Martina Kluth and Claudia Hube-Magg and Nathaniel Melling and Ronald Simon and Christina M{\"o}ller-Koop and P. Hern{\'a}ndez Weigand and Sarah Minner and Alexander Haese* and Hans Uwe Michl and Maria Christina Tsourlakis and Frank Jacobsen and Andrea Hinsch and Corinna Wittmer and Patrick Lebok and Stefan Steurer and Jakob R Izbicki and Guido Sauter and Till Krech and Franziska B{\"u}scheck and Till Sebastian Clauditz and Thorsten Schlomm and Waldemar Wilczak},
  pages={31494 - 31508}
FAM13C, a gene with unknown function is included in several mRNA signatures for prostate cancer aggressiveness. To understand the impact of FAM13C on prognosis and its relationship to molecularly defined subsets, we analyzed FAM13C expression by immunohistochemistry on a tissue microarray containing 12,400 prostate cancer specimens. Results were compared to phenotype, ERG status, genomic deletions of 3p, 5q, 6q and PTEN, and biochemical recurrence. FAM13C was detectable in cell nuclei of… 

Figures and Tables from this paper

A Ten-N6-Methyladenosine (m6A)-Modified Gene Signature Based on a Risk Score System Predicts Patient Prognosis in Rectum Adenocarcinoma

This study identified potential m6A-modified genes that may be involved in the pathophysiology of READ and constructed a novel gene expression panel for READ risk stratification and prognosis prediction.

Investigation of the effects of overexpression of jumping translocation breakpoint (JTB) protein in MCF7 cells for potential use as a biomarker in breast cancer.

The overexpressed JTB condition was significantly associated with an increased expression of ACTNs, FLNA, FLNB, EZR, MYOF, COL3A1, COL11 a1, HSPA1A, HSP90A, WDR, EPPK1, FASN and FOXA1 proteins related to deregulation of cytoskeletal organization and biogenesis.

Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline.

  • S. EggenerR. B. Rumble H. Beltran
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2019
PURPOSE This guideline provides recommendations for available tissue-based prostate cancer biomarkers geared toward patient selection for active surveillance, identification of clinically significant

Meta-Analysis of SNPs Determining Litter Traits in Pigs

It is shown that litter traits studied across pig populations have only a few genomic regions in common based on candidate gene comparison, and the most promising gene was SOSTDC1, which was confirmed to affect male fertility in other mammals.



HOXB13 overexpression is an independent predictor of early PSA recurrence in prostate cancer treated by radical prostatectomy

The prognostic value of HOXB13 was independent from established parameters including Gleason, stage, nodal stage and PSA, and appears to be a promising candidate for clinical routine tests either alone or in combination with other markers, including AR and P SA.

Loss of CDKN1B/p27Kip1 expression is associated with ERG fusion-negative prostate cancer, but is unrelated to patient prognosis

The present data demonstrated that elevated p27 expression was often unrelated to prostate cancer phenotype, and the lack of an effect of the p27 protein levels on PSA recurrence following radical prostatectomy indicated that factors other than p27expression are likely to be the major determinants of prostate cancer recurrence.

Recurrent deletion of 3p13 targets multiple tumour suppressor genes and defines a distinct subgroup of aggressive ERG fusion‐positive prostate cancers

The data show that deletion of 3p13 defines a distinct and aggressive molecular subset of ERG+ prostate cancers, which is possibly driven by inactivation of multiple tumour suppressors.

Cytoplasmic Accumulation of Sequestosome 1 (p62) Is a Predictor of Biochemical Recurrence, Rapid Tumor Cell Proliferation, and Genomic Instability in Prostate Cancer

This study identifies cytoplasmic accumulation of p62 as a strong predictor of an adverse prognostic behavior of prostate cancer independently from established clinicopathologic findings.

Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions

MAP3K7 deletion is identified as a prominent feature in ERG-negative prostate cancer with strong association to tumor aggressiveness and lacking evidence for inactivation through hypermethylation indicates MAP3k7 as a gene for which haploinsufficency is substantially tumorigenic.

βIII-tubulin overexpression is an independent predictor of prostate cancer progression tightly linked to ERG fusion status and PTEN deletion.

TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signaling

The TMPRSS2-ERG gene fusion results in the modulation of transcriptional patterns and cellular pathways with potential consequences for prostate cancer progression suggest the fusion status should be considered in retrospective and future studies to assess biomarkers for prostate cancers detection, progression and targeted therapy.