Family study in Addisonian pernicious anemia.

Abstract

Pernicio 1s anemia. The introduction of vitamin B,2 absorption tests based on the use of isotopically labeled vitamin B,22 and of microbiological assay of vitamin B,2 in serum led to these important investigations being applied in the study of relatives of patients with pernicious anemia. Callender and Denborough carried out ‘Co-vitamin B,2 absorption tests in 52 relatives who had achlorhvdria. In 10 the urinary excretion of vitamin B,2 was within the range found in pernicious anemia and in another 16 the result was less than the value found in controls. McIntyre et al.’ carried out vitamin B,2 ab: orption tests on 106 relatives of 34 patients with pernicious anemia. A low excretion (less than 12.5 per cent of an 0.5 izg. oral dose) was found in 21 of these relatives, although only one fell in the so-called pernicious anemia range-i.e., less than 5 per cent. The majority of these subjects had hydrochloric acid in the gastric secretion. The last few years have seen the introduction of acceptable methods for the detection of antibodies against gastric parietal cells and against gastric intrinsic factor.M,1 Further, the methods used for the detection of intrinsic factor antibodies are also applicable to the direct assay of the intrinsic factor content of gastric juice. Parietal cell antibodies are found in the sera of over 80 per cent of patients with pernicious anemia and intrinsic factor antibodies are found in over 55 per cent. Te Velde et al.” studied 220 relatives of patients with pernicious anemia. Parietal cell antibodies were found in 42 relatives, but in only 9 of 178 control

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@article{Ardeman1966FamilySI, title={Family study in Addisonian pernicious anemia.}, author={S Ardeman and I Chanarin and A Jacobs and L Griffiths}, journal={Blood}, year={1966}, volume={27 5}, pages={599-610} }