Family of human Na+,K+‐ATPase genes Structure of the gene for the catalytic subunit (αIII‐form) and its relationship with structural features of the protein

  title={Family of human Na+,K+‐ATPase genes Structure of the gene for the catalytic subunit ($\alpha$III‐form) and its relationship with structural features of the protein},
  author={Yu. A. Ovchinnikov and Galina Sergeevna Monastyrskaya and Natalia E. Broude and Yuri A Ushkaryov and A M Melkov and Yu.V. Smirnov and I. V. Malyshev and Rando Allikmets and Maria B Kostina and Irina Dulubova and Nikita Kiyatkin and Alexander V Grishin and Nikolai N. Modyanov and Eugene D. Sverdlov},
  journal={FEBS Letters},
Human Na+, K+ ‐ATPase genes
Molecular genetics of Na,K-ATPase.
Gene Structure and Regulation of Gastric Proton Pump
It is demonstrated by cDNA cloning that novel zinc finger proteins that bind to a sequence motif in the 5’-upstream regions of the H+/K+-ATPase α and β subunit genes are present in the gastric mucosal layer.


Primary structure of the alpha-subunit of human Na,K-ATPase deduced from cDNA sequence.
Total genomic Southern hybridization indicated the existence of at most two copies, possibly only one, of the gene encoding the Na,K-ATPase alpha-subunit in the human genome.
Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA
A complementary DNA for the catalytic subunit of the sheep kidney sodium / potassium-dependent ATPase is isolated and characterized and is linked to the phosphorylation site by a 60-amino-acid conserved sequence that may be a major channel for energy transduction.
Primary structure of the α-subunit of Torpedo californica (Na+ + K+)ATPase deduced from cDNA sequence
Cloned and sequenced DNA complementary to the Torpedo californica electroplax messenger RNA encoding the α-subunit of (Na+ + K+)ATPase is cloned and deduced the complete ammo-acid sequence of the polypeptide.
Multiple genes encode the human Na+,K+-ATPase catalytic subunit.
  • M. Shull, J. Lingrel
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1987
A human genomic library was constructed and screened with hybridization probes derived from sheep and rat cDNAs encoding the alpha and alpha(+) isoforms, respectively, of the Na+,K+-ATPase catalytic subunit cDNA sequences but do not correspond to any previously identified isoforms.
Distantly related sequences in the alpha‐ and beta‐subunits of ATP synthase, myosin, kinases and other ATP‐requiring enzymes and a common nucleotide binding fold.
Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.