Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans.

Abstract

Kinetochores form the fundamental link between chromosomal domains termed centromeres and spindle microtubules in all eukaryotes. This connection, provided by a large, multiprotein complex, is essential for precise chromosome segregation and thus ensures genetic stability. Here, we review recent insights into the composition and function of centromeric… (More)
DOI: 10.1016/j.tcb.2013.01.010

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