Family history of autoimmune diseases is associated with an increased risk of autism in children: A systematic review and meta-analysis

@article{Wu2015FamilyHO,
  title={Family history of autoimmune diseases is associated with an increased risk of autism in children: A systematic review and meta-analysis},
  author={Shunquan Wu and Yingying Ding and Fuquan Wu and Ruisheng Li and Guoming Xie and Jun Hou and Pan-yong Mao},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2015},
  volume={55},
  pages={322-332}
}
Parental autoimmune and autoinflammatory disorders as multiple risk factors for common neurodevelopmental disorders in offspring: a systematic review and meta-analysis
TLDR
A major difference in the strength of the association was found in the AID-specific analyses, suggesting that AID increase the risk of NDD by a shared mechanism but that a specific maternal route appears to represent an additional excess risk.
Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses
TLDR
Future studies of ASD risk factors would benefit from a developmental psychopathology approach, prospective design, precise exposure measurement, reliable timing of exposure in relation to critical developmental periods and should take into account the dynamic interplay between gene and environment by using genetically informed designs.
A nationwide study of the risks of major mental disorders among the offspring of parents with rheumatoid arthritis
TLDR
Maternal RA, but not paternal RA or mothers diagnosed with RA before childbirth, was associated with increased risks of multiple mental disorders in their offspring, suggesting potential contributions of maternal genetic factors to ASDs and ADHD development in offspring.
Family history of immune conditions and autism spectrum and developmental disorders: Findings from the study to explore early development
  • L. Croen, Yinge X. Qian, O. Zerbo
  • Psychology, Medicine
    Autism research : official journal of the International Society for Autism Research
  • 2019
TLDR
Maternal history of eczema/psoriasis and asthma was associated with a 20%–40% increased odds of both ASD and DD, and associations may differ by ASD phenotype of the child.
Proband and Familial Autoimmune Diseases Are Associated With Proband Diagnosis of Autism Spectrum Disorders.
Maternal Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Risk for Autism Spectrum Disorders in Offspring: A Meta-analysis
TLDR
Pooled results by using random-effects models suggested that maternal RA was associated with an increased risk for ASDs [odds ratio (OR) 1.39, 95% confidence interval (CI)1.16–1.67], while maternal SLE wasassociated with an increase risk for AsDs only in western population (OR 1.91, 95%; further study is warranted to confirm these results).
Parental Rheumatoid Arthritis and Autism Spectrum Disorders in Offspring: A Danish Nationwide Cohort Study.
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References

SHOWING 1-10 OF 37 REFERENCES
Association of Family History of Autoimmune Diseases and Autism Spectrum Disorders
TLDR
The observed associations between familial autoimmunity and ASDs/infantile autism are probably attributable to a combination of a common genetic background and a possible prenatal antibody exposure or alteration in fetal environment during pregnancy.
Prenatal risk factors for autism: comprehensive meta-analysis
TLDR
There is insufficient evidence to implicate any one prenatal factor in autism aetiology, although there is some evidence to suggest that exposure to pregnancy complications may increase the risk.
Familial Autoimmune Thyroid Disease as a Risk Factor for Regression in Children with Autism Spectrum Disorder: A CPEA Study
A multicenter study of 308 children with Autism Spectrum Disorder (ASD) was conducted through the Collaborative Programs of Excellence in Autism (CPEA), sponsored by the National Institute of Child
Familial Clustering of Autoimmune Disorders and Evaluation of Medical Risk Factors in Autism
TLDR
An increased number of autoimmune disorders suggests that in some families with autism, immune dysfunction could interact with various environmental factors to play a role in autism pathogenesis.
Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study.
TLDR
It is suggested that maternal autoimmune disorders present in women around the time of pregnancy are unlikely to contribute significantly to autism risk, and further etiologic investigations are needed to confirm these results.
The CHARGE Study: An Epidemiologic Investigation of Genetic and Environmental Factors Contributing to Autism
TLDR
The CHARGE (Childhood Autism Risks from Genetics and Environment) study will address a wide spectrum of chemical and biologic exposures, susceptibility factors, and their interactions, and Phenotypic variation among children with autism will be explored.
Autoimmune diseases in parents of children with infantile autism: a case—control study
TLDR
Comparing the rates and types of autoimmune disease in the parents of 111 patients with infantile autism with a matched control group of parents of 330 children from the general population found two autoimmune conditions were associated with IA: ulcerative colitis in mothers and type 1 diabetes in fathers.
Frequency of Gastrointestinal Symptoms in Children with Autistic Spectrum Disorders and Association with Family History of Autoimmune Disease
TLDR
There was no association between a family history of autoimmune disease and GI symptoms in children with ASD and the multivariate analysis, autism and food selectivity were associated with GI symptoms.
Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group.
TLDR
A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
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