Family history and the risk of prostate cancer

  title={Family history and the risk of prostate cancer},
  author={Gary Steinberg and Bob S. Carter and Terri H. Beaty and Barton Childs and Patrick C. Walsh},
  journal={The Prostate},
A case‐control study was performed to estimate the relative risk of developing prostate cancer for men with a positive family history. Extensive cancer pedigrees were obtained on 691 men with prostate cancer and 640 spouse controls. 

Heredity and prostate cancer: A study of World War II veteran twins

Increased risk of prostate cancer among men with a family history of the disease has been observed in several epidemiological studies, and family studies have identified hereditary prostate cancer

Family history facilitates the early diagnosis of prostate carcinoma

The influence of family history on the risk of prostate carcinoma and current understanding of factors that increase this risk are outlined.

Clinical and pathologic characteristics of familial prostate cancer in Asian population

We investigated prevalence of familial and hereditary prostate cancer (PCa) in Asian population, and compared clinical characteristics between familial and sporadic disease.


Authors' conclusions Breast and prostate cancer are the second leading causes of death and the most frequently diagnosed malignancies in Canadian women and men, respectively. Age, ethnicity, and

Identification of Genetic Risk Factors for Prostate Cancer: Analytic Approaches Using Hereditary Prostate Cancer Families

In 2009, prostate cancer is the most commonly diagnosed nonskin cancer among men in the United States, and a leading cause of cancer-related mortality, with an estimated 27,360 related deaths.

Population‐based risk assessment for other cancers in relatives of hereditary prostate cancer (HPC) cases

To identify associations of other cancers with hereditary prostate cancer (HPC) we estimated relative risks (RRs) of 36 different cancers in relatives of prostate cancer cases in the Utah Population

Tumour Genetics (Prostate/Testis/Penis)

A family history is a major risk factor for prostate cancer and brothers of men with testis cancer have an eight- to tenfold risk themselves oftestis cancer.

Familial aggregation of prostate cancer in African‐Americans and white Americans

It is shown that the incidence of prostate cancer in first‐degree family members of African‐Americans with that in white Americans is higher than that in other ethnic groups.

A population‐based study of clinical and pathological prognostic characteristics of men with familial and

To compare traditional prognostic characteristics of familial vs sporadic prostate cancers and to investigate potential detection biases arising from differences in the use of screening and



Environmental factors and breast and prostatic cancer.

Differences in hormone profiles in cancer patients and in patients with an increasing number of potential risk factors together with differences n life style and diet suggest a relationship between diet, hormonal metabolism, and these endocrine-associated cancers.

Epidemiology of cancer of the prostate

No significant relationship was found to socioeconomic status, marital status, fertility, social habits, previous diseases, weight, height, hair distribution, or laboratory data.

Review: Prostate cancer epidemiology

Despite the public health importance of prostate cancer, it has received only moderate epidemiologic study and the etiologic importance of diet, endocrine function, genetic susceptibility, and other possible determinants of prostrate cancer risk is uncertain.

Family history and the risk of breast cancer.

The risk of breast cancer for a woman was higher if her first-degree relative had unilateral rather than bilateral breast cancer or had breast cancer detected at a younger rather than older age.

Characteristics of familial colon cancer in a large population data base

The results suggest that factors other than those that predispose to the rare syndromes are important in determining familial risk for common colon cancers, and that the presence of these two clinical features should not suggest the absence of familial risk of colorectal cancer.

Concerning a familial association between breast cancer and both prostatic and uterine malignancies

The familial incidence and distribution of all malignancies for a group of 145 breast cancer patients were determined and compared to that of 139 randomized control patients and significantly higher incidences of only uterine, prostatic, and breast cancer were found among both maternal and paternal relatives of the Breast cancer patients.

Familial factors affecting prostatic cancer risk and plasma sex‐steroid levels

Preliminary data suggest that the metabolic clearance rate of testosterone and the conversion ratio of testosterone to estradiol are relatively high in probands and that plasma androgen values in families with prostatic cancer cluster in the lower range of normal, and plasma sex‐steroid content is more similar in each brothers with or without prostaticcancer than among nonbrothers.